Acute Coronary Syndromes Compendium
نویسندگان
چکیده
Lipoproteins represent major risk factors, both positive and negative, for atherosclerotic cardiovascular disease. The major plasma lipid traits, low-density lipoprotein cholesterol (LDL-C), triglycerides, and high-density lipoprotein cholesterol (HDL-C) are all predictive of cardiovascular risk and have been considered targets for therapeutic intervention. Here, we specifically consider the role of these lipids and lipoproteins in the setting of acute coronary syndrome (ACS) and review their changes in ACS, their predictive ability for recurrent events, and their status as therapeutic targets in patients with ACS. LDL as a Biomarker and Therapeutic Target in ACS LDL-C is a negative acute phase reactant that was shown to fall by a maximum of 50% at 7 days after an acute myocardial infarction (MI) in an era before therapies that limit infarct size were known or widely used. The magnitude of reduction in LDL-C was in proportion to the myocardial injury and inflammatory response after an acute coronary syndrome (ACS). Similar observations were seen in the Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering Acute Coronary Syndromes Compendium
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Acute Coronary Syndromes Compendium
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